The primary mission of the Imaging Technology Group (ITG) is to provide state-of-the-art imaging facilities for researchers at the Beckman Institute for Advanced Science and Technology and University of Illinois. This service mission is accomplished through two facilities: the Microscopy Suite and the Visualization Laboratory.

A secondary mission of the ITG is to develop advanced imaging technologies with an emphasis on projects in remote instrument control and scientific visualization.

Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

03 Nov 2009

Mammalian neurons from the rat hippocampus and hypothalamus were cultured for direct neuropeptide analysis using mass spectrometry. As graphically depicted here, a crystalline matrix is formed on the cultured neurons to extract and retain the neuropeptides, which are then profiled using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. This composite image was created using Maya and Photoshop software packages, and produced by collaboration between Larry Millet (Martha Gillette Lab) and Janet Sinn-Hanlon (ITG Visualization Laboratory). The image appears in the article "Direct Cellular Peptidomics of Supraoptic Magnocellular and Hippocampal Neurons in Low-Density Cocultures" by Larry J. Millet, Adriana Bora, Jonathan V. Sweedler and Martha U. Gillette. The paper will be published in the first issue of the online journal "ACS Chemical Neuroscience"; the article is currently available online at http://pubs.acs.org/journal/acncdm. Jonathan Sweedler and Martha Gillette are both faculty in the NeuroTech group at the Beckman Institute.

Image Courtesy: Larry Millet, Janet Hanlon
Contact: millet@illinois.edu

ITG Forum

Tuesday, November 10, 2009
MRI for Intra-Procedural Optimization of Liver-Directed Cancer Therapies

Speaker: Andrew Larson , Assistant Professor, Radiology and Biomedical Engineering, NWU Feinberg School of Medicine

Time: 12:00PM

Location: Room 5602

Abstract:

Transcatheter and percutaneous liver-directed approaches are widely used for the treatment of liver tumors. These therapies include transcatheter arterial chemoembolization (TACE), radioembolization, and percutaneous ablation. Intra-procedural imaging guidance may be critical to optimize outcomes. During the talk I will describe our recent pre-clinical and translational work focused upon the development and validation of new magnetic resonance imaging methods for intra-procedural monitoring of tumor perfusion changes during TACE, depiction of intra-hepatic radioembolization microsphere delivery, and monitoring tissue ablation zones during percutaneous irreversible electroporation procedures.

ITG News

ITG Creates Journal of Biophotonics Cover

The November 2009 edition of the Journal of Biophotonics features a cover created by ITG Staff Alex Jerez in the Visualization Laboratory. Jerez created the cover artwork to accompany the feature story "Imaging engineered tissues using structural and functional optical coherence tomography" by Xing Liang, Benedikt W. Graf, and Stephen A. Boppart of the University of Illinois at Urbana-Champaign.

Posted: 2009-10-29

Biophysical Journal Cover by ITG

The October 21, 2009 edition of the Biophysical Journal features a cover created by Olga Svinarski and ITG staff in the Visualization Laboratory. Staff members Alex Jerez and Zach Johnson collaborated with Svinarski, using 3D modeling and compositing techniques to make the final rendered image. The cover artwork accompanies a feature story titled "Common Structural Transitions in Explicit-Solvent Simulations of Villin Headpiece Folding" by Peter L. Freddolino and Klaus Schulten, both of the University of Illinois at Urbana-Champaign.

Posted: 2009-10-29

Analytical Chemistry Cover by ITG

ITG Staff Alex Jerez, Zach Johnson, and Eric Shoemaker collaborated to create the cover of the September 15, 2009 edition of the journal Analytical Chemistry in the Visualization Laboratory. The cover image depicts microfabricated electrodes and molecular interaction via functionalized particles and it accompanies the feature article by Sang Woo Lee of Yonsei University and Rashid Bashir of the University of Illinois Urbana-Champaign, titled Dielectrophoretic Technique for Measurement of Chemical and Biological Interactions.

Posted: 2009-10-07

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